LRRTM4

Across TCGA cell cohorts, LRRTM4 mutation is significantly associated with the RNA expression of many other genes, with 110 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LRRTM4-associated genes across cancer lineages are KRTAP4-1, TECRL, and LORICRIN. Each is linked with LRRTM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRTM4-to-partner and partner-to-LRRTM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-1 grouped by LRRTM4-low versus LRRTM4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRTM4→partner) and Y-score (partner→LRRTM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP4-1 →	+0.129	+4.452	<.001	.001	3	2
BLOOD_Myeloma	TECRL →	+0.038	+3.906	<.001	.007	3	1
BLOOD_Leukemia	LORICRIN →	+0.495	+4.339	<.001	.002	3	1
BLOOD_Leukemia	KRTAP6-3 →	+0.150	+4.984	<.001	.002	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
LUNG_SCLC	MAGEB3 →	+0.153	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

KRTAP4-1 by LRRTM4 expression — BLOOD_Lymphoma

Explore this box plot interactively →