LRRTM4

Across TCGA cell cohorts, LRRTM4 mutation is significantly associated with the mutation status of many other genes, with 1,971 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRTM4-associated genes across cancer lineages are SCN8A, RBM20, and HOXD3. Each is linked with LRRTM4 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRTM4-to-partner and partner-to-LRRTM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCN8A grouped by LRRTM4-low versus LRRTM4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRTM4→partner) and Y-score (partner→LRRTM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SCN8A →	+3.437	+3.977	<.001	<.001	1	4
STOMACH	RBM20 →	+4.807	+4.807	.008	.008	1	4
BLOOD_Leukemia	HOXD3 →	+3.635	+3.635	.003	.003	1	4
UPPER_AERODIGESTIVE_TRACT	PDCD11 →	+4.392	+4.954	.008	.008	1	4
CNS	WIZ →	+4.044	+5.000	.008	.008	1	4
LUNG_NSCLC_LUAD	PLCE1 →	+3.469	+2.548	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,971 associations by consensus.

SCN8A by LRRTM4 expression — LUNG_SCLC

Explore this box plot interactively →