LRRTM2

Across TCGA patient cohorts, LRRTM2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRTM2-associated genes across cancer lineages are ATM, IGFBP2, and JNK2. Each is linked with LRRTM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRTM2-to-partner and partner-to-LRRTM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by LRRTM2-low versus LRRTM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRTM2→partner) and Y-score (partner→LRRTM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.500	-2.308	.002	.033	3	2
UCEC	IGFBP2 →	-0.774	-3.321	.001	.009	3	1
UCEC	JNK2 →	+0.191	+1.502	.009	.030	3	1
UCEC	MEK1 →	+0.345	+2.736	.010	<.001	3	1
UCEC	NDRG1_pT346 →	-0.437	-1.847	.015	.008	3	1
UCEC	p62 Lck ligand →	+0.299	+1.847	.012	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by LRRTM2 expression — UCEC

Explore this box plot interactively →