LRRTM2

Across TCGA pan-cancer cohorts, LRRTM2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LRRTM2 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher LRRTM2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LRRTM2 expression acts as an unfavorable survival marker, although some lineages such as LIHC and SKCM show a favorable association.

UVM, LIHC, and SKCM are the cancer types where LRRTM2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.439	0.803	<.001	130	view →
LIHC	OS	Quartile	III,IV	0.675	0.245	<.001	61	view →
SKCM	OS	Median	III,IV	0.488	0.308	<.001	50	view →
KIRC	DFS	Tertile	All	0.945	0.792	.002	44	view →
LGG	DFS	Median	All	0.544	0.303	<.001	31	view →
BRCA	OS	Median	III,IV	0.881	0.774	.006	26	view →
THCA	OS	Quartile	All	0.766	1.000	.005	25	view →
LUAD	DFS	Quartile	III,IV	0.650	0.211	.012	24	view →
LUSC	OS	Tertile	III,IV	0.241	0.575	.001	20	view →
LAML	DFS	Tertile	All	0.675	0.308	.003	18	view →
MESO	OS	Tertile	IV	0.368	0.814	.030	9	view →
PCPG	DFS	Median	All	0.958	0.815	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LRRTM2–UVM (OS)

Open the UVM breakdown →