LRRTM2

Across TCGA cell cohorts, LRRTM2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LRRTM2-associated genes across cancer lineages are SLITRK3, KLHL40, and MYMK. Each is linked with LRRTM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRTM2-to-partner and partner-to-LRRTM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLITRK3 grouped by LRRTM2-low versus LRRTM2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRTM2→partner) and Y-score (partner→LRRTM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLITRK3 →	+0.044	+4.874	<.001	.002	3	1
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1
BLOOD_Lymphoma	MYMK →	+0.054	+5.209	<.001	.005	3	1
LARGE_INTESTINE	IL20 →	+0.275	+3.662	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SLITRK3 by LRRTM2 expression — BLOOD_Leukemia

Explore this box plot interactively →