LRRTM1

Across TCGA patient cohorts, LRRTM1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRTM1-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and MSH6. Each is linked with LRRTM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRTM1-to-partner and partner-to-LRRTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LRRTM1-low versus LRRTM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRTM1→partner) and Y-score (partner→LRRTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.720	+1.697	<.001	.012	3	4
STAD	4E-BP1 →	+0.315	+3.169	.032	.019	3	3
LUAD	MSH6 →	+0.278	+2.700	.029	.006	3	2
LUAD	Bcl-xL →	-0.194	-2.309	.002	.033	3	2
UCEC	JNK_pT183_Y185 →	-0.153	-1.847	.005	.007	3	2
UCEC	MAPK_pT202_Y204 →	-0.322	-2.102	.034	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Caspase-7-cleavedD198 by LRRTM1 expression — UCEC

Explore this box plot interactively →