LRRTM1

Across TCGA pan-cancer cohorts, LRRTM1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LRRTM1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where LRRTM1 RNA is repressed in tumor relative to normal tissue. In most cancer types LRRTM1 is over-expressed in tumor, although a few such as BLCA and HNSC show the opposite, repressed pattern.

BLCA, KICH, and HNSC are the cancer types where LRRTM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRTM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−0.767	<.001	11	view →
KICH	Male	All	+3.599	<.001	8	view →
HNSC	Female	All	−0.150	<.001	8	view →
COAD	Male	II,III,IV	−0.735	<.001	7	view →
KIRC	Male	All	−0.157	<.001	7	view →
STAD	All	All	−0.684	<.001	6	view →
BRCA	All	All	−0.044	<.001	6	view →
KIRP	All	All	−0.226	<.001	5	view →
THCA	Male	II,III,IV	−1.837	<.001	4	view →
LUAD	All	All	+0.327	.007	4	view →
LUSC	All	III,IV	−0.101	<.001	3	view →
UCEC	All	All	+1.873	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LRRTM1–BLCA

Open the BLCA breakdown →