LRRTM1

Across TCGA cell cohorts, LRRTM1 mutation is significantly associated with the RNA expression of many other genes, with 481 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRTM1-associated genes across cancer lineages are GRM6, SPZ1, and GTSF1L. Each is linked with LRRTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRTM1-to-partner and partner-to-LRRTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRM6 grouped by LRRTM1-low versus LRRTM1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRTM1→partner) and Y-score (partner→LRRTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GRM6 →	+0.024	+3.177	.004	.004	3	2
OESOPHAGUS	SPZ1 →	+0.530	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	GTSF1L →	+0.037	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	KRTAP10-5 →	+0.014	+4.662	<.001	.005	3	1
OVARY	GK2 →	+0.006	+5.807	<.001	.001	3	1
OVARY	KRTAP26-1 →	+0.020	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 481 associations by consensus.

GRM6 by LRRTM1 expression — BLOOD_Leukemia

Explore this box plot interactively →