LRRTM1

Across TCGA cell cohorts, LRRTM1 mutation is significantly associated with the mutation status of many other genes, with 5,462 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRTM1-associated genes across cancer lineages are PNPLA6, ATP8B3, and WIPF3. Each is linked with LRRTM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRRTM1-to-partner and partner-to-LRRTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA6 grouped by LRRTM1-low versus LRRTM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRTM1→partner) and Y-score (partner→LRRTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PNPLA6 →	+2.544	+2.977	<.001	<.001	1	5
LARGE_INTESTINE	ATP8B3 →	+2.667	+2.544	<.001	<.001	1	5
SOFT_TISSUE	WIPF3 →	+5.502	+5.502	.003	.003	1	4
BLOOD_Leukemia	CHD6 →	+2.360	+2.741	.003	.003	1	4
BLOOD_Lymphoma	UBR4 →	+3.384	+4.169	<.001	<.001	1	4
BLOOD_Lymphoma	KDM2B →	+3.969	+4.523	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,462 associations by consensus.

PNPLA6 by LRRTM1 expression — LARGE_INTESTINE

Explore this box plot interactively →