LRRN4CL

Across TCGA patient cohorts, LRRN4CL mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRN4CL-associated genes across cancer lineages are RNU6-194P, RNU6-806P, and RNU6-877P. Each is linked with LRRN4CL in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRN4CL-to-partner and partner-to-LRRN4CL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-194P grouped by LRRN4CL-low versus LRRN4CL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRN4CL→partner) and Y-score (partner→LRRN4CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-194P →	+0.800	+4.475	<.001	.002	3	1
UCEC	RNU6-806P →	+0.511	+4.750	<.001	.005	3	1
UCEC	RNU6-877P →	+1.160	+4.888	<.001	<.001	3	1
UCEC	RNU6-701P →	+0.486	+4.386	.001	.002	3	1
UCEC	RNU6-80P →	+0.769	+3.976	<.001	.006	3	1
UCEC	RNU6-933P →	+0.634	+4.184	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

RNU6-194P by LRRN4CL expression — UCEC

Explore this box plot interactively →