LRRN4

Across TCGA cell cohorts, LRRN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,340 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible LRRN4-associated GO terms across cancer lineages are Regulation of intracellular transport, Assembly of actomyosin apparatus involved in cytokinesis, and Actomyosin contractile ring assembly. Each is linked with LRRN4 in more than 9 cancer types. Because this analysis shows association rather than direction, both LRRN4-to-partner and partner-to-LRRN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intracellular transport grouped by LRRN4-low versus LRRN4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRN4→partner) and Y-score (partner→LRRN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of intracellular transport →	+0.051	+0.264	<.001	.001	3	10
BREAST	Assembly of actomyosin apparatus involved in cytokinesis →	+0.171	+0.214	<.001	<.001	3	9
BREAST	Actomyosin contractile ring assembly →	+0.171	+0.214	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Secondary metabolic process →	-0.223	-0.779	<.001	<.001	3	8
BREAST	Positive regulation of neuromuscular junction development →	+0.131	+0.180	.001	.006	3	8
BREAST	Protein K11-linked ubiquitination →	+0.062	+0.181	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,340 associations by consensus.

Regulation of intracellular transport by LRRN4 expression — BREAST

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