LRRN3

Across TCGA cell cohorts, LRRN3 mutation is significantly associated with the RNA expression of many other genes, with 147 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRN3-associated genes across cancer lineages are SCYGR8, GPR143, and CEACAM3. Each is linked with LRRN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRN3-to-partner and partner-to-LRRN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCYGR8 grouped by LRRN3-low versus LRRN3-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRN3→partner) and Y-score (partner→LRRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SCYGR8 →	+0.026	+5.169	<.001	.004	3	1
BLOOD_Lymphoma	GPR143 →	+0.109	+3.424	<.001	.006	3	1
BLOOD_Lymphoma	CEACAM3 →	+0.101	+3.342	<.001	.001	3	1
BLOOD_Lymphoma	C5orf52 →	+0.013	+3.662	<.001	.009	3	1
BLOOD_Lymphoma	GALP →	+0.013	+3.472	<.001	.002	3	1
BLOOD_Lymphoma	PSG11 →	+0.036	+3.129	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 147 associations by consensus.

SCYGR8 by LRRN3 expression — BONE

Explore this box plot interactively →