LRRIQ1

Across TCGA patient cohorts, LRRIQ1 mutation is significantly associated with the RNA expression of many other genes, with 5,682 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRIQ1-associated genes across cancer lineages are PSMC3IP, SNRPB, and KIF23. Each is linked with LRRIQ1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRRIQ1-to-partner and partner-to-LRRIQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMC3IP grouped by LRRIQ1-low versus LRRIQ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRIQ1→partner) and Y-score (partner→LRRIQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMC3IP →	+0.653	+1.747	<.001	<.001	3	5
LUAD	SNRPB →	+0.449	+1.901	<.001	.001	3	5
UCEC	KIF23 →	+0.519	+1.776	<.001	<.001	3	5
SKCM	SMARCD1 →	+0.267	+1.680	.006	<.001	3	5
STAD	SSRP1 →	+0.575	+3.472	<.001	.002	3	4
UCEC	INCENP →	+0.480	+1.868	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,682 associations by consensus.

PSMC3IP by LRRIQ1 expression — UCEC

Explore this box plot interactively →