LRRIQ1

Across TCGA pan-cancer cohorts, LRRIQ1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LRRIQ1 data layer compared with 11 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher LRRIQ1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LRRIQ1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

LGG, STAD, and BRCA are the cancer types where LRRIQ1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.743	0.869	<.001	46	view →
STAD	OS	Median	II,III,IV	0.608	0.732	.008	44	view →
BRCA	OS	Median	III,IV	0.891	0.761	.004	39	view →
LIHC	DFS	Quartile	All	0.389	0.574	<.001	25	view →
UCS	OS	Median	III,IV	0.550	0.206	.017	20	view →
KIRP	DFS	Median	All	0.976	0.795	.007	17	view →
UVM	DFS	Tertile	II,III,IV	0.799	0.529	.025	14	view →
BLCA	DFS	Quartile	IV	0.180	0.573	.001	11	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	10	view →
ESCA	OS	Median	All	1.000	0.670	.026	9	view →
DLBC	OS	Median	All	0.953	0.536	.017	8	view →
SKCM	OS	Median	All	0.843	0.709	.004	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LRRIQ1–LGG (OS)

Open the LGG breakdown →