LRRIQ1

Across TCGA patient cohorts, LRRIQ1 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRIQ1-associated genes across cancer lineages are 4E-BP1_pT70, ASNS, and FoxM1. Each is linked with LRRIQ1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRIQ1-to-partner and partner-to-LRRIQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by LRRIQ1-low versus LRRIQ1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRIQ1→partner) and Y-score (partner→LRRIQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	4E-BP1_pT70 →	+0.271	+2.129	<.001	.009	3	4
UCEC	ASNS →	+0.435	+1.584	<.001	<.001	3	4
STAD	FoxM1 →	+0.307	+2.115	.002	.017	3	3
STAD	PCNA →	+0.232	+3.321	.040	.009	3	3
STAD	ACVRL1 →	-0.246	-2.786	.003	.003	3	3
STAD	Notch1 →	+0.197	+2.321	.002	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

4E-BP1_pT70 by LRRIQ1 expression — LUSC

Explore this box plot interactively →