LRRIQ1

Across TCGA cell cohorts, LRRIQ1 mutation is significantly associated with the RNA expression of many other genes, with 401 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRIQ1-associated genes across cancer lineages are CARD6, SPATA22, and KIAA1217. Each is linked with LRRIQ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRIQ1-to-partner and partner-to-LRRIQ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARD6 grouped by LRRIQ1-low versus LRRIQ1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRIQ1→partner) and Y-score (partner→LRRIQ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CARD6 →	-0.997	-3.232	.002	.008	3	3
BLOOD_Myeloma	SPATA22 →	+0.253	+3.906	.001	.009	3	2
BLOOD_Lymphoma	KIAA1217 →	+1.501	+3.276	.001	.004	3	2
BLOOD_Lymphoma	TMPRSS3 →	+2.021	+3.276	.003	.004	3	2
LARGE_INTESTINE	ME2 →	+1.217	+3.364	<.001	.002	3	2
BLOOD_Leukemia	LGI1 →	+0.035	+3.124	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 401 associations by consensus.

CARD6 by LRRIQ1 expression — BLOOD_Leukemia

Explore this box plot interactively →