LRRC8E

Across TCGA pan-cancer cohorts, LRRC8E mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LRRC8E data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LRRC8E mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LRRC8E expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where LRRC8E mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.522	.003	20	view →
PDAC	OS	Median	All	0.198	0.709	.027	9	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.909	.037	2	view →
LSCC	DFS	Tertile	III,IV	0.875	0.410	.042	1	view →
LUAD	DFS	Median	II,III,IV	0.867	0.834	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LRRC8E–UCEC (OS)

Open the UCEC breakdown →