LRRC8E

Across TCGA pan-cancer cohorts, LRRC8E RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of LRRC8E’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LRRC8E RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC8E is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, HNSC, and BLCA are the cancer types where LRRC8E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC8E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.119	<.001	11	view →
HNSC	Male	All	+0.658	<.001	10	view →
BLCA	Male	III,IV	+0.848	.005	7	view →
UCEC	All	All	+0.574	<.001	6	view →
BRCA	All	II,III,IV	+0.500	<.001	6	view →
KIRP	Female	All	+0.499	<.001	6	view →
READ	All	All	+0.797	<.001	5	view →
LUSC	Male	II,III,IV	+0.511	<.001	5	view →
KICH	Female	All	−0.486	<.001	5	view →
LIHC	All	All	+0.218	<.001	5	view →
LUAD	Female	II,III,IV	+0.249	.014	3	view →
PAAD	All	All	+0.492	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

LRRC8E–COAD

Open the COAD breakdown →