LRRC8E

Across TCGA patient cohorts, LRRC8E protein abundance is significantly associated with the RNA expression of many other genes, with 4,395 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible LRRC8E-associated genes across cancer lineages are RAB3D, PRDX2, and MAP2K7. Each is linked with LRRC8E in more than 4 cancer types. Because this analysis shows association rather than direction, both LRRC8E-to-partner and partner-to-LRRC8E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRRC8E versus RAB3D in OV, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8E→partner) and Y-score (partner→LRRC8E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RAB3D →	+0.791	+0.311	.001	.001	3	5
OV	PRDX2 →	+0.813	+0.333	.004	<.001	3	3
OV	MAP2K7 →	+0.548	+0.337	.002	<.001	3	3
CCRCC	MEOX2 →	-2.408	-0.652	<.001	.001	3	3
HNSC	PERP →	+0.881	+0.500	<.001	<.001	3	3
HNSC	SH2D3A →	+0.508	+0.429	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,395 associations by consensus.

LRRC8E vs RAB3D — OV

Explore this scatter interactively →