LRRC8E

Across TCGA patient cohorts, LRRC8E mutation is significantly associated with the RNA expression of many other genes, with 893 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC8E-associated genes across cancer lineages are CWC25, MIR7702, and ODF1. Each is linked with LRRC8E in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC8E-to-partner and partner-to-LRRC8E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CWC25 grouped by LRRC8E-low versus LRRC8E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8E→partner) and Y-score (partner→LRRC8E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CWC25 →	+0.370	+3.016	.005	<.001	3	2
UCEC	MIR7702 →	+0.163	+3.738	<.001	.009	3	2
HNSC	ODF1 →	+0.128	+4.010	<.001	.006	3	2
COAD	SNORD113-4 →	+0.882	+4.126	<.001	.004	3	2
SKCM	RN7SL228P →	+0.067	+4.408	<.001	.005	3	2
SKCM	MIR8082 →	+0.336	+3.490	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 893 associations by consensus.

CWC25 by LRRC8E expression — UCEC

Explore this box plot interactively →