LRRC8E

Across TCGA patient cohorts, LRRC8E mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC8E-associated genes across cancer lineages are IGFBP2, Annexin-1, and Notch1. Each is linked with LRRC8E in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC8E-to-partner and partner-to-LRRC8E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by LRRC8E-low versus LRRC8E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8E→partner) and Y-score (partner→LRRC8E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.873	-2.115	.002	.019	3	2
UCEC	Annexin-1 →	+0.560	+2.189	.014	.034	3	2
UCEC	Notch1 →	+0.173	+2.115	.004	.019	3	1
UCEC	p62 Lck ligand →	+0.429	+2.594	.002	.006	3	1
UCEC	PDK1_pS241 →	+0.162	+2.833	.029	.034	3	1
UCEC	Cyclin-B1 →	+0.660	+2.115	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

IGFBP2 by LRRC8E expression — UCEC

Explore this box plot interactively →