LRRC8E

Across TCGA cell cohorts, LRRC8E mutation is significantly associated with the RNA expression of many other genes, with 190 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC8E-associated genes across cancer lineages are OR13D1, NDST4, and OR10H5. Each is linked with LRRC8E in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC8E-to-partner and partner-to-LRRC8E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13D1 grouped by LRRC8E-low versus LRRC8E-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8E→partner) and Y-score (partner→LRRC8E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR13D1 →	+0.032	+4.217	<.001	.005	3	2
BLOOD_Leukemia	NDST4 →	+0.128	+4.342	<.001	.002	3	1
BLOOD_Leukemia	OR10H5 →	+0.076	+3.922	<.001	.002	3	1
BLOOD_Leukemia	CCDC197 →	+0.053	+3.684	<.001	.004	3	1
BLOOD_Leukemia	TRIM60 →	+0.021	+4.201	<.001	.001	3	1
BLOOD_Leukemia	OR10Q1 →	+0.010	+3.969	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 190 associations by consensus.

OR13D1 by LRRC8E expression — URINARY_TRACT

Explore this box plot interactively →