LRRC8C

Across TCGA pan-cancer cohorts, LRRC8C Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LRRC8C data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LRRC8C Mutation is associated with better overall survival. In most high-consensus cancer types, elevated LRRC8C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, BLCA, and SCLC are the cancer types where LRRC8C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.456	.009	24	view →
BLCA	DFS	Median	All	0.152	0.627	<.001	15	view →
SCLC	DFS	Median	All	0.192	0.793	.017	6	view →
SKCM	DFS	Median	IV	0.040	0.454	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LRRC8C–UCEC (OS)

Open the UCEC breakdown →