LRRC8C

Across TCGA pan-cancer cohorts, LRRC8C RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LRRC8C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LRRC8C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC8C is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where LRRC8C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC8C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.991	<.001	12	view →
KIRC	Female	All	+1.138	<.001	11	view →
LUAD	Female	III,IV	−1.171	<.001	8	view →
KICH	Female	All	−1.136	<.001	8	view →
COAD	All	All	−0.366	<.001	7	view →
UCEC	All	All	−1.566	<.001	6	view →
BRCA	All	III,IV	−1.141	<.001	6	view →
LUSC	All	II,III,IV	−0.914	<.001	6	view →
STAD	All	II,III,IV	+0.694	.002	6	view →
KIRP	All	All	−0.494	<.001	5	view →
LIHC	Female	II,III,IV	+0.568	.013	4	view →
ESCA	All	All	+1.199	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LRRC8C–HNSC

Open the HNSC breakdown →