LRRC8C

Across TCGA pan-cancer cohorts, LRRC8C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LRRC8C data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher LRRC8C mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LRRC8C expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LSCC, GBM, and OV are the cancer types where LRRC8C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.921	1.000	.011	9	view →
GBM	DFS	Quartile	All	0.885	0.591	.012	8	view →
OV	DFS	Median	All	0.809	1.000	.022	4	view →
CCRCC	OS	Median	IV	0.233	0.789	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LRRC8C–LSCC (OS)

Open the LSCC breakdown →