LRRC8C

Across TCGA patient cohorts, LRRC8C protein abundance is significantly associated with the protein abundance of many other proteins, with 21,681 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LRRC8C-associated proteins across cancer lineages are CYBA, CYBA_T147, and CYBB. Each is linked with LRRC8C in more than 6 cancer types. Because this analysis shows association rather than direction, both LRRC8C-to-partner and partner-to-LRRC8C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRRC8C versus CYBA in BRCA, with a Pearson correlation of 0.57.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8C→partner) and Y-score (partner→LRRC8C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CYBA →	+0.623	+0.681	<.001	<.001	3	7
UCEC	CYBA_T147 →	+1.249	+0.482	<.001	.003	3	7
UCEC	CYBB →	+1.303	+0.716	<.001	<.001	3	7
GBM	FMNL1 →	+0.671	+0.349	<.001	<.001	3	7
UCEC	FMNL1_S1031 →	+1.747	+0.781	<.001	<.001	3	7
BRCA	GIMAP1 →	+0.546	+0.810	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,681 associations by consensus.

LRRC8C vs CYBA — BRCA

Explore this scatter interactively →