LRRC8C

Across TCGA patient cohorts, LRRC8C mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC8C-associated genes across cancer lineages are Notch1, Tuberin, and HER3. Each is linked with LRRC8C in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC8C-to-partner and partner-to-LRRC8C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by LRRC8C-low versus LRRC8C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8C→partner) and Y-score (partner→LRRC8C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.204	+2.321	<.001	.001	3	2
UCEC	Tuberin →	+0.332	+2.115	<.001	.016	3	2
BRCA	HER3 →	-0.351	-3.000	.047	.038	3	1
BRCA	PKC-a →	+0.396	+3.000	<.001	.038	2	2
BRCA	Smac →	-0.398	-3.000	.013	.037	3	1
UCEC	JNK2 →	+0.234	+1.925	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Notch1 by LRRC8C expression — UCEC

Explore this box plot interactively →