LRRC8C

Across TCGA cell cohorts, LRRC8C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,499 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC8C-associated GO terms across cancer lineages are Nucleocytoplasmic transport, Adenylate cyclase-activating serotonin receptor signaling pathway, and Mitotic spindle assembly. Each is linked with LRRC8C in more than 11 cancer types. Because this analysis shows association rather than direction, both LRRC8C-to-partner and partner-to-LRRC8C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleocytoplasmic transport grouped by LRRC8C-low versus LRRC8C-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8C→partner) and Y-score (partner→LRRC8C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Nucleocytoplasmic transport →	+0.066	+1.302	<.001	<.001	3	12
LIVER	Adenylate cyclase-activating serotonin receptor signaling pathway →	-0.196	-1.308	<.001	.003	3	12
LARGE_INTESTINE	Mitotic spindle assembly →	+0.074	+0.964	.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.052	+1.046	.003	.009	2	12
LUNG_NSCLC_LUSC	Positive regulation of cytoskeleton organization →	+0.085	+1.373	.003	.005	3	11
BREAST	Positive regulation of cell cycle process →	+0.092	+1.063	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,499 associations by consensus.

Nucleocytoplasmic transport by LRRC8C expression — BREAST

Explore this box plot interactively →