LRRC8C

Across TCGA cell cohorts, LRRC8C mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LRRC8C-associated genes across cancer lineages are OR10W1, REG1B, and BANF2. Each is linked with LRRC8C in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC8C-to-partner and partner-to-LRRC8C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by LRRC8C-low versus LRRC8C-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8C→partner) and Y-score (partner→LRRC8C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10W1 →	+0.008	+4.196	<.001	.006	3	2
LARGE_INTESTINE	REG1B →	+2.507	+4.196	<.001	.002	3	1
BREAST	BANF2 →	+0.287	+3.672	<.001	.006	3	1
BREAST	GPR119 →	+0.014	+3.963	<.001	.003	3	1
BREAST	TRIM64B →	+0.126	+3.672	<.001	.006	3	1
BREAST	PNMA6F →	+0.031	+4.312	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR10W1 by LRRC8C expression — BREAST

Explore this box plot interactively →