LRRC8C-DT

Across TCGA pan-cancer cohorts, LRRC8C-DT RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated LRRC8C-DT data layer.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher LRRC8C-DT RNA is associated with better overall survival. In most high-consensus cancer types, elevated LRRC8C-DT expression acts as an unfavorable survival marker, although some lineages such as PAAD and BRCA show a favorable association.

PAAD, BRCA, and CESC are the cancer types where LRRC8C-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Tertile	All	0.754	0.396	<.001	66	view →
BRCA	DFS	Quartile	All	0.592	0.468	.002	55	view →
CESC	OS	Tertile	All	0.915	0.762	.003	34	view →
UCEC	OS	Tertile	All	0.885	0.953	.003	34	view →
LUSC	DFS	Tertile	III,IV	0.309	0.994	.003	30	view →
LUAD	OS	Median	All	0.853	0.771	.005	23	view →
KIRP	DFS	Quartile	II,III,IV	0.291	1.000	.012	22	view →
SKCM	DFS	Median	All	0.670	0.566	.001	22	view →
READ	DFS	Median	II,III,IV	0.936	0.704	.005	21	view →
SARC	OS	Quartile	All	0.834	0.672	.013	10	view →
LIHC	DFS	Tertile	All	0.378	0.212	.029	10	view →
GBM	DFS	Quartile	All	0.487	0.185	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

LRRC8C-DT–PAAD (OS)

Open the PAAD breakdown →