LRRC8C-DT

Across TCGA pan-cancer cohorts, LRRC8C-DT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LRRC8C-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LRRC8C-DT RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC8C-DT is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRP are the cancer types where LRRC8C-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC8C-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.741	<.001	11	view →
KICH	Female	II,III,IV	−1.368	<.001	10	view →
KIRP	Female	All	−0.643	<.001	9	view →
HNSC	All	III,IV	+0.383	<.001	9	view →
UCEC	All	All	−1.313	<.001	6	view →
BRCA	All	III,IV	−1.166	<.001	6	view →
LUAD	Female	III,IV	−0.755	<.001	6	view →
LUSC	All	III,IV	−0.741	<.001	6	view →
COAD	All	II,III,IV	−0.223	<.001	6	view →
CHOL	All	All	+0.423	<.001	2	view →
READ	All	All	−0.342	.009	2	view →
PRAD	All	All	−0.217	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LRRC8C-DT–THCA

Open the THCA breakdown →