Across TCGA pan-cancer cohorts, LRRC8B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LRRC8B data layer compared with 19 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LRRC8B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LRRC8B expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where LRRC8B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.932	0.581	.007	16	view →
UCEC	OS	Median	All	1.000	0.414	.003	8	view →
PDAC	OS	Median	II,III,IV	0.113	0.582	.031	3	view →
GBM	DFS	Median	All	0.780	0.654	.022	2	view →
LUAD	DFS	Median	All	0.222	0.650	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: LRRC8B tumor-vs-normal RNA expression · all LRRC8B data types