Across TCGA patient cohorts, LRRC8B RNA expression is significantly associated with the protein abundance of many other proteins, with 13,693 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LRRC8B-associated proteins across cancer lineages are WNK2_S1862, CAV1, and AAAS. Each is linked with LRRC8B in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRC8B-to-partner and partner-to-LRRC8B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8B→partner) and Y-score (partner→LRRC8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WNK2_S1862 →	+1.179	+0.774	<.001	<.001	3	4
HNSC	CAV1 →	-0.627	-0.711	<.001	<.001	3	4
UCEC	AAAS →	+0.227	+0.521	<.001	.001	3	4
COAD	GTF2B →	+0.271	+0.346	<.001	.005	3	4
COAD	TIMELESS_S1173 →	+0.714	+0.591	<.001	<.001	3	4
LSCC	TRIM33 →	+0.289	+0.553	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,693 associations by consensus.

Exploration

LRRC8B survival (RNA) · tumor vs normal (RNA) · all LRRC8B data types