Across TCGA patient cohorts, LRRC8B protein abundance is significantly associated with the RNA expression of many other genes, with 6,189 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LRRC8B-associated genes across cancer lineages are GFOD1, PRDM8, and TSHR. Each is linked with LRRC8B in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC8B-to-partner and partner-to-LRRC8B results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8B→partner) and Y-score (partner→LRRC8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GFOD1 →	+1.243	+0.736	.006	.003	3	2
GBM	PRDM8 →	+0.816	+0.304	<.001	<.001	3	2
OV	TSHR →	+1.591	+0.823	.004	.009	3	2
GBM	CORO6 →	+0.788	+0.469	<.001	<.001	3	2
OV	ZEB2 →	+0.854	+0.652	.004	.002	3	2
OV	IGIP →	+0.838	+0.761	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,189 associations by consensus.

Exploration

LRRC8B survival (RNA) · tumor vs normal (RNA) · all LRRC8B data types