Across TCGA patient cohorts, LRRC8B mutation is significantly associated with the RNA expression of many other genes, with 3,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC8B-associated genes across cancer lineages are TRAJ50, SNORD114-9, and RNU6-1032P. Each is linked with LRRC8B in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC8B-to-partner and partner-to-LRRC8B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8B→partner) and Y-score (partner→LRRC8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	TRAJ50 →	+0.403	+7.977	<.001	.007	3	3
STAD	SNORD114-9 →	+0.412	+3.745	<.001	.005	3	2
HNSC	RNU6-1032P →	+0.233	+7.954	<.001	.008	3	2
SKCM	SMSP1 →	+0.039	+3.838	<.001	<.001	3	2
LUSC	STAU2P1 →	+0.132	+4.329	<.001	.003	3	2
LUSC	F8A2 →	+0.036	+3.956	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,668 associations by consensus.

Exploration

LRRC8B survival (RNA) · tumor vs normal (RNA) · all LRRC8B data types