Across TCGA patient cohorts, LRRC8B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC8B-associated genes across cancer lineages are 14-3-3_beta, eEF2, and ERK2. Each is linked with LRRC8B in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC8B-to-partner and partner-to-LRRC8B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8B→partner) and Y-score (partner→LRRC8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.082	-1.847	.018	.049	3	1
UCEC	eEF2 →	+0.410	+2.584	<.001	.001	3	1
UCEC	ERK2 →	+0.205	+2.415	.002	.003	3	1
UCEC	GAPDH →	+0.491	+2.415	.008	.003	3	1
UCEC	GATA6 →	-0.110	-1.655	.044	.011	3	1
UCEC	Heregulin →	-0.116	-1.678	.006	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

LRRC8B survival (RNA) · tumor vs normal (RNA) · all LRRC8B data types