Across TCGA cell cohorts, LRRC8B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,277 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC8B-associated GO terms across cancer lineages are External encapsulating structure organization, Negative regulation of chromosome condensation, and Nuclear pore complex assembly. Each is linked with LRRC8B in more than 11 cancer types. Because this analysis shows association rather than direction, both LRRC8B-to-partner and partner-to-LRRC8B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8B→partner) and Y-score (partner→LRRC8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	External encapsulating structure organization →	-0.187	-1.636	.003	<.001	3	12
LARGE_INTESTINE	Negative regulation of chromosome condensation →	+0.150	+0.757	<.001	.003	3	11
LIVER	Nuclear pore complex assembly →	+0.123	+1.183	.004	.007	3	11
LIVER	Extracellular matrix organization →	-0.190	-1.636	.003	<.001	3	11
LUNG_NSCLC_LUSC	Collagen fibril organization →	-0.312	-1.177	<.001	<.001	3	11
LIVER	Extracellular structure organization →	-0.191	-1.636	.003	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,277 associations by consensus.

Exploration

LRRC8B survival (RNA) · tumor vs normal (RNA) · all LRRC8B data types