Across TCGA cell cohorts, LRRC8B mutation is significantly associated with the RNA expression of many other genes, with 477 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC8B-associated genes across cancer lineages are PDILT, DEFB131B, and CCL7. Each is linked with LRRC8B in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC8B-to-partner and partner-to-LRRC8B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8B→partner) and Y-score (partner→LRRC8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PDILT →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	DEFB131B →	+0.279	+5.000	<.001	.006	3	1
BLOOD_Lymphoma	CCL7 →	+0.122	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	TMCO5A →	+0.156	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	DYDC1 →	+1.404	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR5P3 →	+0.031	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 477 associations by consensus.

Exploration

LRRC8B survival (RNA) · tumor vs normal (RNA) · all LRRC8B data types