LRRC8A

Across TCGA patient cohorts, LRRC8A RNA expression is significantly associated with the protein abundance of many other proteins, with 14,131 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible LRRC8A-associated proteins across cancer lineages are NIBAN2, RABL6, and S100A2. Each is linked with LRRC8A in more than 5 cancer types. Because this analysis shows association rather than direction, both LRRC8A-to-partner and partner-to-LRRC8A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRRC8A versus NIBAN2 in OV, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8A→partner) and Y-score (partner→LRRC8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NIBAN2 →	+0.584	+0.989	<.001	<.001	3	6
OV	RABL6 →	+0.256	+0.532	<.001	<.001	3	6
LSCC	S100A2 →	+1.570	+0.717	<.001	<.001	3	5
OV	TRAF2 →	+0.317	+0.691	<.001	<.001	3	5
UCEC	ANXA2 →	+0.429	+0.480	<.001	<.001	3	5
OV	FZD1 →	+0.916	+0.760	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,131 associations by consensus.

LRRC8A vs NIBAN2 — OV

Explore this scatter interactively →