LRRC8A

Across TCGA pan-cancer cohorts, LRRC8A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated LRRC8A data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LRRC8A RNA is associated with better overall survival. In most high-consensus cancer types, elevated LRRC8A expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

KIRC, ACC, and SCLC are the cancer types where LRRC8A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.740	0.504	<.001	108	view →
ACC	OS	Median	All	0.381	0.794	<.001	100	view →
SCLC	DFS	Median	II,III,IV	0.773	0.412	<.001	79	view →
BLCA	DFS	Quartile	III,IV	0.344	0.683	<.001	60	view →
HNSC	OS	Median	All	0.286	0.439	.002	56	view →
LGG	DFS	Median	All	0.503	0.290	<.001	50	view →
PAAD	DFS	Tertile	All	0.180	0.434	.001	48	view →
UVM	DFS	Median	All	0.436	0.772	<.001	45	view →
LUAD	DFS	Quartile	All	0.568	0.787	<.001	44	view →
COAD	DFS	Tertile	All	0.734	0.849	<.001	33	view →
UCEC	DFS	Median	IV	0.846	0.521	.009	32	view →
MESO	OS	Median	II,III,IV	0.465	0.651	.002	31	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

LRRC8A–KIRC (OS)

Open the KIRC breakdown →