LRRC8A

Across TCGA patient cohorts, LRRC8A mutation is significantly associated with the RNA expression of many other genes, with 3,355 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC8A-associated genes across cancer lineages are BUB3, CDK1, and SLC25A33. Each is linked with LRRC8A in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC8A-to-partner and partner-to-LRRC8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by LRRC8A-low versus LRRC8A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8A→partner) and Y-score (partner→LRRC8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.404	+1.485	<.001	.003	3	3
UCEC	CDK1 →	+0.512	+2.186	.007	.001	3	3
UCEC	SLC25A33 →	+0.563	+1.917	<.001	<.001	3	3
UCEC	MSANTD3 →	+0.410	+1.917	.001	<.001	3	3
UCEC	NANS →	+0.458	+1.969	<.001	.002	3	3
UCEC	UTP11 →	+0.395	+1.960	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,355 associations by consensus.

BUB3 by LRRC8A expression — UCEC

Explore this box plot interactively →