LRRC8A

Across TCGA cell cohorts, LRRC8A mutation is significantly associated with the RNA expression of many other genes, with 194 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC8A-associated genes across cancer lineages are AVP, TECTB, and C10orf53. Each is linked with LRRC8A in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC8A-to-partner and partner-to-LRRC8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by LRRC8A-low versus LRRC8A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8A→partner) and Y-score (partner→LRRC8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	TECTB →	+0.063	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	C10orf53 →	+0.021	+4.867	.001	.009	3	1
BLOOD_Lymphoma	FAM25C →	+0.351	+5.209	<.001	.005	3	1
CNS	IAPP →	+0.163	+3.774	<.001	.008	3	1
CNS	SLC22A7 →	+0.035	+4.087	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 194 associations by consensus.

AVP by LRRC8A expression — BLOOD_Lymphoma

Explore this box plot interactively →