LRRC74A

Across TCGA pan-cancer cohorts, LRRC74A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LRRC74A data layer compared with 23 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher LRRC74A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC74A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SARC, SCLC, and UCEC are the cancer types where LRRC74A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	DFS	Median	All	0.146	0.615	<.001	12	view →
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	12	view →
UCEC	DFS	Median	All	0.964	0.624	.013	10	view →
BLCA	DFS	Median	IV	0.064	0.476	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LRRC74A–SARC (DFS)

Open the SARC breakdown →