LRRC74A

Across TCGA pan-cancer cohorts, LRRC74A RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of LRRC74A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where LRRC74A RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC74A is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and BRCA are the cancer types where LRRC74A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC74A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−0.236	<.001	9	view →
LUSC	Male	II,III,IV	−0.200	<.001	8	view →
BRCA	All	III,IV	−0.198	<.001	6	view →
COAD	All	II,III,IV	+0.125	<.001	6	view →
CHOL	All	II,III,IV	+0.544	.009	5	view →
KICH	All	All	−0.088	<.001	5	view →
UCEC	All	All	−0.108	.007	2	view →
THCA	All	All	−0.037	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

LRRC74A–LUAD

Open the LUAD breakdown →