LRRC74A

Across TCGA patient cohorts, LRRC74A mutation is significantly associated with the RNA expression of many other genes, with 1,698 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC74A-associated genes across cancer lineages are GNPNAT1, SLC52A3, and NME1-NME2. Each is linked with LRRC74A in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC74A-to-partner and partner-to-LRRC74A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPNAT1 grouped by LRRC74A-low versus LRRC74A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC74A→partner) and Y-score (partner→LRRC74A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNPNAT1 →	+0.519	+1.880	.003	.004	3	2
UCEC	SLC52A3 →	-0.848	-2.404	<.001	.003	3	2
UCEC	NME1-NME2 →	+0.536	+2.343	<.001	.003	3	2
UCEC	WNT6 →	-0.859	-2.478	.006	.001	3	2
UCEC	PLAGL1 →	-0.576	-2.486	.003	.001	3	2
UCEC	SPRYD7 →	+0.331	+2.008	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,698 associations by consensus.

GNPNAT1 by LRRC74A expression — UCEC

Explore this box plot interactively →