LRRC74A

Across TCGA patient cohorts, LRRC74A mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC74A-associated genes across cancer lineages are ACC1, EGFR, and Caspase-7-cleavedD198. Each is linked with LRRC74A in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC74A-to-partner and partner-to-LRRC74A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by LRRC74A-low versus LRRC74A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC74A→partner) and Y-score (partner→LRRC74A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.299	+1.887	.022	.029	3	3
SKCM	EGFR →	-0.164	-2.321	.044	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.427	+1.720	.045	.025	3	2
UCEC	CD49b →	-0.286	-2.787	.005	.003	3	2
UCEC	Cyclin-B1 →	+0.683	+2.584	<.001	.010	3	2
SKCM	PI3K-p110-a →	+0.205	+2.824	.007	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ACC1 by LRRC74A expression — UCEC

Explore this box plot interactively →