Across TCGA patient cohorts, LRRC73 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC73-associated genes across cancer lineages are TUBB4BP3, RNY4P3, and MIR3648-1. Each is linked with LRRC73 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC73-to-partner and partner-to-LRRC73 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC73→partner) and Y-score (partner→LRRC73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBB4BP3 →	+0.270	+2.561	<.001	.006	3	2
SKCM	RNY4P3 →	+0.443	+4.531	.001	.005	3	2
BRCA	MIR3648-1 →	+0.267	+7.473	<.001	.007	3	1
BRCA	MIR610 →	+0.294	+4.683	<.001	.007	3	1
BRCA	MIR676 →	+0.246	+4.883	.002	.006	3	1
BRCA	TSPY18P →	+0.072	+7.473	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Exploration

LRRC73 survival (RNA) · tumor vs normal (RNA) · all LRRC73 data types