Across TCGA pan-cancer cohorts, LRRC73 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LRRC73’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where LRRC73 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC73 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
COAD, KICH, and LIHC are the cancer types where LRRC73 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC73 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.