Across TCGA cell cohorts, LRRC73 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC73-associated genes across cancer lineages are EPPIN, HHLA1, and EDDM3B. Each is linked with LRRC73 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC73-to-partner and partner-to-LRRC73 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC73→partner) and Y-score (partner→LRRC73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPPIN →	+0.006	+5.507	<.001	<.001	3	1
BLOOD_Leukemia	HHLA1 →	+0.011	+4.551	<.001	.004	3	1
BLOOD_Leukemia	EDDM3B →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR1D4 →	+0.046	+4.539	<.001	.007	3	1
LARGE_INTESTINE	CDH20 →	+0.104	+4.029	<.001	.001	3	1
LARGE_INTESTINE	SLC39A12 →	+0.092	+3.700	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

LRRC73 survival (RNA) · tumor vs normal (RNA) · all LRRC73 data types