LRRC71

Across TCGA patient cohorts, LRRC71 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC71-associated genes across cancer lineages are EGFR_pY1173, ERK2, and FOXO3a_pS318_S321. Each is linked with LRRC71 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC71-to-partner and partner-to-LRRC71 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by LRRC71-low versus LRRC71-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC71→partner) and Y-score (partner→LRRC71) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.074	+2.611	.046	.006	3	1
UCEC	ERK2 →	+0.240	+2.999	.007	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.131	-2.312	.024	.034	3	1
UCEC	GSK-3_pS9 →	-0.405	-2.999	.031	.035	3	1
UCEC	HER3_pY1289 →	+0.084	+3.189	.037	.010	3	1
UCEC	MAPK_pT202_Y204 →	-0.561	-2.584	.010	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1173 by LRRC71 expression — UCEC

Explore this box plot interactively →